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Neuroscientist Cori Bargmann is leading the new Chan Zuckerberg Initiative's $3 billion effort to cure or prevent "all diseases" by the end of this century. She talks about that daunting task.

Hillary Clinton and Donald Trump are focusing on their closing arguments to voters in key battleground states with two weeks to go until Election Day.

Going on patrol along the U.S.-Mexico border with the Three Percent United Patriots — amped up and equipped with night vision goggles — felt like going to war, says journalist Shane Bauer.

China's Communist Party will aim to tighten party discipline at a key meeting this week. Part of this is an effort to target covert factions within the party that threaten to destabilize it.

Boeing reported a big cut in profits on Wednesday as the 737 Max remains grounded. The company fired a top executive as questions remain about when the Max will return to service.

NPR's Ailsa Chang speaks with Paul Farrell, a lead attorney representing local governments who are seeking settlements in the ongoing opioid litigation.

New testimony in the impeachment inquiry puts acting chief of staff Mick Mulvaney at the center of the Ukraine scandal. Mulvaney's management style may have contributed by loosening protocols.

Lebanese politicians of all stripes are under attack from protesters demanding better services.

A three judge panel in the 2nd Circuit Court of Appeals heard oral arguments on Wednesday in Trump v. Vance, one of the ongoing battles over the release of President Trump's tax returns.

House Republicans stormed a secure meeting room on Capitol Hill Wednesday where three House committees were in the middle of closed door testimony as part of the impeachment inquiry.

UN Secretary General Ban Ki-moon is working to wring commitments out of 55 nations to ratify the Paris Climate Change treaty.

Drug czar Pablo Escobar's son studied to be an architect. But his late father's notoriety interfered with business, so today he's a speaker urging kids to stay away from drugs.

Officials are investigating an explosion that happened in Manhattan Saturday night. NPR's Rachel Martin gets the latest.

At the height of her addiction to heroin, Tracey Helton Mitchell lived in an alley and sold her body. Now she works as an addiction specialist helping others. Her new memoir is The Big Fix.

One of the best known indigenous and environmental rights leaders was murdered in her hometown in Honduras. Renee Montagne talks to human rights activist Annie Bird about Berta Cáceres' death.

Obama says they're putting off a move when his term is up so Sasha can finish high school in Washington, D.C. It's been 95 years since a president stayed on in the nation's capital after his term.

Gen. James Mattis broke ranks with the Obama administration and left his post in charge of U.S. Central Command over his fixation on Iran as a threat to the U.S. Mattis is known as an independent thinker in the military. His past statements put him at odds with some of Donald Trump's views as well.

It's not just Earth, Wind & Fire who'd like you to remember September. The words in this week's puzzle each start with one of the first three letters of our current month.

The house Alan Moore was born in was torn down in 1969 — along with most of the rest of his neighborhood. But in his new novel, Jerusalem, the legendary comics creator brings it all back to life.

NPR's Mary Louise Kelly talks with former Ambassador to Venezuela Patrick Duddy about the Trump administration's push to oust Nicolás Maduro as president of Venezuela.

Federal employees will receive backpay when the government reopens. Federal contractors will not, but some in Congress are trying to change that.

The World Bank is searching for a new president after the last one abruptly resigned. The position has traditionally gone to an American, but there could be international competition this time around.

The Invisibles looks at an under-reported aspect of the Holocaust. It's a docudrama, opening in the U.S. Friday, about Jews who survived in Berlin, a city the Nazis had proclaimed "Jew-free."

President Trump announced he agreed to sign a stopgap spending bill to end the partial government shutdown. The deal, reached with top congressional leaders, does not include money for his border wall.

A partial cease-fire in Syria seems to be unraveling after a U.S. airstrike resulted in dozens of deaths of Syrian government troops. Rachel Martin gets an update from Liz Sly of The Washington Post.