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Iran's supreme leader warned Sunday that any attack by the United States would spark a "regional war" in the Mideast, further escalating tensions as President Donald Trump has threatened to militarily strike the Islamic Republic.

About half of U.S. rural hospitals operate in the red on a good day. Now facing a pandemic, hospital CEOs warn that, without federal help, their doors may close when the community most needs them.

The immediate impact of the cargo decline affects virtually every business around the ports, but port officials say this downturn will soon be felt much more broadly.

Long a Southern staple, Duke's Mayo is racking up converts among professional chefs across the U.S. But few know the surprising backstory of Eugenia Duke, the woman behind the century-old brand.

The American Cancer Society has spent a lot of time in Washington opposing President Trump’s efforts to repeal and replace the Affordable Care Act. But...

Cleanup and recovery from Hurricane Michael is slow, costly and ongoing. As donations to the area stall and media coverage fades, some residents of the...

Short Wave's scientist in residence Regina Barber talks with NASA astronaut Josh Cassada about daily life on the International Space Station.

After a stroke, people often lose dexterity in one hand. Now, the Food and Drug Administration has authorized a device that can restore function by encouraging the brain to rewire.

One of the worst tornadoes in U.S. history struck Joplin, Mo., a little over 10 years ago. Despite a massive recovery effort, the survivors still bear psychological scars.

Christopher Scott served over a decade in prison, and there he developed a passion for soap operas. Now free, he still keeps his appointment with General Hospital.

Among the demands from Russia was a guarantee that Ukraine be permanently barred from NATO membership. That would violate a U.S. "core principle," Secretary of State Antony Blinken said Wednesday.

NPR's Michel Martin speaks with Mark Esper about his forthcoming book, "A Sacred Oath: Memoirs of a Secretary of Defense During Extraordinary Times."

If you're a Washington power broker, your status is symbolized by the photographs decorating your office wall: those with you standing next to congressmen, cabinet officers or even the president. Madeleine Brand discusses so-called "glory walls" with John Dickerson, chief political correspondent for Slate.

In Egypt, where antiquities have stood for millennia, climate change is posing new threats to an ancient country and its people.

Flooding cut off I-75 for hours as officials struggle to restore power and water to residents in the path of the storm's destruction.

Russian missiles ruptured Mykolaiv's pipelines. They stretch across territory under Russian control, making it impossible for municipal workers to repair them. With winter coming, worries are rising.

The Russian president accused Ukrainian special services of carrying out an attack on the Kerch Bridge, a key supply line for Russian forces.

Dr. Frank Dumont never thought of himself as being on the front lines of suicide prevention. But after the death of a patient he was particularly close to, he sees his role changing. He's seeking to reduce suicides by asking his patients about guns in their homes.

What more can the United Nations do, as Russia's war in Ukraine enters its second year? NPR's Michel Martin speaks to Linda Thomas-Greenfield, the U.S. ambassador to the United Nations.

NPR's A Martinez speaks with Kieren Barnes of Mercy Corps about the earthquake and relief efforts in northwestern Syria.

The incoming Israeli ruling coalition agreements will make it the country's most religious and right-wing government in history, potentially putting it at odds with large parts of the Israeli public.

Wisconsin voters upended Republican control of that state's supreme court for the first time in 15 years. This race was also the most expensive judicial race in American history.

This was another wild week at Twitter after CEO Elon Musk gave staff an ultimatum to stay or go, and it seems many people are choosing the latter. What's the future of the social network?

The Alabama Republican senator counted himself as one of Donald Trump's earliest supporters on Capitol Hill. Now, he's in line to become the next U.S. attorney general.

The former vice president is calling for unity and compromise, a restoration, of sort, of what Democrats view as normalcy. For Bernie Sanders and his supporters, that's hardly enough.