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The 4-decades long effort to create an AIDS vaccine suffered a blow with news that a vaccine in a late stage trial was discontinued because results showed it to be ineffective. What are the obstacles?

Large chains like Panera and P.F. Chang's as well as neighborhood hangouts are increasingly experimenting with the subscription model as a way to ensure steady revenue and customer visits.

Neither candidate was above the 50% threshold needed to win outright under Georgia law. This sets up a post-Thanksgiving showdown in what is already the country's most expensive Senate race.

Art lovers − expert, casual and novice − will pack Julian B. Lane Riverfront Park this weekend as the area's top talent will showcase their works for the 53rd year.

It was just over a month ago that hundreds of extremist supporters of former President Jair Bolsonaro, stormed the capital and ransacked the Congress, Supreme Court and the presidential offices.

Trump and his company have repeatedly faced criminal investigations but this case marks the first time his company has been charged, tried, and convicted on criminal charges.

The 31-year-old Los Angeles Dodgers star got an unprecedented two-season suspension without pay for violating the league's domestic violence and sexual assault policy. He can resume play this spring.

A series of storms are ushering in the new year with downpours and flooding across much of the state and multiple feet of snow in the Sierra Nevada.

The world's No.2 economy grew by 3% in 2022, less than half of the previous year's rate, official data showed Tuesday as China faced pressure from anti-virus controls and a real estate slump.

An accused drug dealer has turned the tables and helped prosecutors convict his defense lawyer of manufacturing evidence to help his case. The hard-nosed strategy is raising questions about whether the Justice Department is chilling the relationship between a defendant and his lawyer.

The holiday travel rush is already on, and it could spread out over more days than usual this year. Travel experts say the ability of many people to work remotely is letting them take off early for Thanksgiving or return home later. Crowds are expected to rival those of 2019, the last Thanksgiving before the pandemic.

Former Jefferson High School and Tampa Bay Devil Rays first baseman Fred McGriff was selected by the contemporary baseball era committee over Barry Bonds, Roger Clemens and Curt Schilling. He will be inducted on July 23.

Former President Donald Trump is preparing to launch his third campaign for the White House. An announcement was expected at 9 p.m. Tuesday from his club in Palm Beach.

NPR's Ari Shapiro talks with Andrew Weissmann, a former senior prosecutor on the Robert Mueller probe, about what's next for the special counsel on the Trump investigations.

The historic indictment of the former president raises all sorts of legal, political and logistical questions. While it's early days, experts expect a delayed trial after Tuesday's arraignment.

Democrats and Republicans agree that Congress should tighten gun laws by passing universal background checks and red flag laws and require gun licenses as well as increase funding for mental health.

As the highest-ranked team left standing, it's up to No. 4 seed UConn to restore order in a tournament that's been marked by wild upsets. But it's not the only team with a strong resume.

After years of high rates, the country hit a new high during the pandemic, far exceeding rates in other developed nations. Black women are at especially high risk.

Hogan said he would not seek the Republican nomination for president. He positioned himself as one of his party's fiercest critics of Donald Trump.

President Biden is using his budget to show how he could cut the deficit and still fund his pledges like universal preschool, paid leave and more childcare funding.

Former President Donald Trump faces three new charges in the case accusing him of hoarding classified documents as a grand jury continues to investigate his role in trying to overturn 2020's election.

Attorneys for former President Donald Trump and his aide Walt Nauta were in a Florida courtroom Tuesday. It's the first pre-trial hearing on classified documents ahead of their federal trial.

In 2016, then-candidate Donald Trump claimed he could shoot someone and not lose any voters. Now, he faces criminal charges in three separate indictments, and voters continue to support "Teflon Don."

NPR's Steve Inskeep talks with Dana Thompson Dorsey of the University of South Florida about the implications of the Supreme Court ruling on affirmative action.

Created by Hormel Foods in 1937 and promoted as "the miracle meat," Spam became K-ration fare for American GIs and Allied forces during World War II. The "war-time delicacy" is still a favorite in Howard Yoon's cupboard. He explains why.